I would raise but not jam.  raise to 2,5-3x so u can get called by weaker hands like two pairs or TP.

I often call here against opponents, the thinking is, aside from QJ or Q9 possibilities, there aren't a ton of two pair combos they likely have, and the big bet really doesn't always gel with 2 pair hands from a lot of opponents on this board (they often make a smaller bet or check).  So a lot of times I think they have bluffs or flushes in their range, and many more bluffs.Of course, that's villain dependent.  Readless in micros I might shove, readless vs competentish avg opponent in higher stakes I might just flat.  But I would look at identifying the types of hands they play, starting preflop and also how they bet various hands, because that's where the "gold" is, so to speak, you can really find a huge difference in the correct decision vs a lot of opponents (for example, a guy that value bets very wide, a shove is almost always going to be better, a guy that bets much smaller in these situations with hands as strong as 2pair, but also bluffs, a call is almost always going to be better).

And of course if you had a read that your opponent would flat hands like A2, or slowplay pre and post hands like AQ/AA/QQ, with QJ/Q9 hands in their range, you'd most likely shove the river here (aside from stuff like "small bets non nuts on scary boards for value").But I think a lot of opponents will 3bet a lot of 2 pair and trips hands on this board, raise A2 on the flop (or call and lead the turn), and have a lot more bluff/flushes in their range on the river when they pot it than 2 pair or slowplayed TP (often slowplaying Ax on the flop doesn't translate into a pot sized river bet either).